Long-married Adi (Surya Saputra) and Kirana (Laudya Chintya Bella) do not have children yet, because Kirana has asthma. Kirana suffered three miscarriages, so she gets more stress and sadness. Adi and Kirana stay with Adi’s mother, Aida (Ivanka Suwandi) who does not like Kirana. To make her more comfortable and away from Aida, Adi takes Kirana to a new house. But it does not make Kirana become more cheerful.
Kirana feels there is something strange in their house. She feels there is other people who is always with her. Kirana is initially frightened, but over time she actually gets on with girl ghost she called Sister (Yafi Tesa Zahara). Kirana familiarity with Sister makes Adi anxious, but Kirana always convince Adi Sister is nice and pleasant. Adi finally accepts the ‘presence’ of Sister because he sees Kirana becoming more cheerful.
All their familiarity with Sister turns into terror when Kirana is pregnant again. Sister is jealous. Aida come to the house to accompany her daughter in law. Aida’s behavior makes her harmed by Sister. Then Sister tries to harm the unborn baby. Adi was not able to defend his wife and the unborn baby from the ‘anger’ of Sister.